Bronchitis Research Today is a free monthly online journal that collates and summarizes the latest research about Bronchitis, including details on pulmonary disorders, symptoms, diagnosis, treatment, prevention.

New diagnostic real-time PCR for specific detection of Parachlamydia acanthamoebae DNA in clinical samples.

Casson N, Posfay-Barbe KM, Gervaix A, Greub G

Center for Research on Intracellular Bacteria, Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne 1011, Switzerland. gilbert.greub@chuv.ch.

Given the low sensitivity of amoebal coculture, we developed a specific real-time PCR for the detection of Parachlamydia. The analytical sensitivity was high, and the inter- and intrarun variabilities were low. When the PCR was applied to nasopharyngeal aspirates, it was positive for six patients with bronchiolitis. Future studies should assess the role of Parachlamydia in bronchiolitis.

Published 4 April 2008 in J Clin Microbiol, 46(4): 1491-3.
Full-text of this article is available online (may require subscription).

Articles on Bronchitis published 2 April 2008:

Prospective multicenter study of bronchiolitis: predicting safe discharges from the emergency department.   Pediatrics, 121(4): 680-8.

OBJECTIVE: Bronchiolitis is the leading cause of hospitalization for infants. Our objective was to identify factors associated with safe discharge to home from the emergency department. METHODS: We conducted a prospective cohort study during 2 consecutive bronchiolitis seasons, from 2004 to 2006. Thirty US emergency departments contributed data. All patients were < 2 years of age and had a final emergency department attending physician diagnosis of bronchiolitis. Using multivariate logistic ... [Abstract] [Full-text]

Articles on Bronchitis published 31 March 2008:

Epithelial tenascin predicts obliterative airway disease.   J Heart Lung Transplant, 27(4): 400-7.

BACKGROUND: Epithelial cell injury, inflammation, fibrosis and airway obliteration result in remodeling of terminal bronchi in post-transplant obliterative bronchiolitis. Tenascin as an extracellular matrix glycoprotein is expressed in several remodeling processes. METHODS: Heterotopic bronchial allografts of pigs were studied to assess tenascin expression during development of post-transplant obliterative bronchiolitis. A total of 157 allografts or autograft controls were serially obtained 2 ... [Abstract] [Full-text]

Articles on Bronchitis published 10 March 2008:

Effects of induction immunosuppression regimen on acute rejection, bronchiolitis obliterans, and survival after lung transplantation.   J Thorac Cardiovasc Surg, 135(3): 594-602.

OBJECTIVE: Effects of daclizumab and antithymocyte globulin induction on acute rejection, bronchiolitis obliterans syndrome, and survival after lung transplantation are unknown. We hypothesized that daclizumab results in less acute rejection and bronchiolitis obliterans and better survival than antithymocyte globulin. METHODS: Consecutive adult lung transplants (n = 163) at the University of Virginia from January 1998 to May 2006 were reviewed. Antithymocyte globulin induction was routinely ... [Abstract] [Full-text]

Articles on Bronchitis published 3 March 2008:

Effect of oxygen supplementation on length of stay for infants hospitalized with acute viral bronchiolitis.   Pediatrics, 121(3): 470-5.

OBJECTIVE: The goal was to establish the final supportive therapy determinants of hospital length of stay for bronchiolitis. METHODS: A retrospective case study of a randomly selected 25% of subjects <1 year of age who were hospitalized with bronchiolitis between April 1, 2003, and June 15, 2005 (n = 129), was performed. Records of 102 admissions to the general wards were reviewed (77 respiratory syncytial virus positive). Length of stay, pulse oxygen saturation profile, oxygen ... [Abstract] [Full-text]

Articles on Bronchitis published 29 February 2008:

Bronchiolitis obliterans in children: clinical presentation, therapy and long-term follow-up.   J Paediatr Child Health, 44(3): 129-33.

AIM: To delineate the predisposing factors, clinical, radiological features and outcomes of bronchiolitis obliterans (BO) in children for minimising morbidity and mortality. METHODS: Ten children who had BO from July 1995 to July 2005 were retrospectively reviewed at a tertiary paediatric facility in northern Taiwan. RESULTS: Bronchiolitis obliterans complicated by infections, Stevens-Johnson syndrome was found in eight and two patients, respectively. In children with post-infectious BO, ... [Abstract] [Full-text]

Articles on Bronchitis published 25 February 2008:

Interaction between smoking and genetic factors in the development of chronic bronchitis.   Am J Respir Crit Care Med, 177(5): 486-90.

RATIONALE: Smoking is a primary risk factor for chronic bronchitis, emphysema, and chronic obstructive pulmonary disease, but since not all smokers develop disease, it has been suggested that some individuals may be more susceptible to exogenous factors, such as smoking, and that this susceptibility could be genetically determined. OBJECTIVES: The aim of the present study was to assess, in a population-based sample of twins, the following: (1) to what extent genetic factors contribute to the ... [Abstract] [Full-text]

Articles on Bronchitis published 21 February 2008:

Ganciclovir/valganciclovir prophylaxis decreases cytomegalovirus-related events and bronchiolitis obliterans syndrome after lung transplantation.   Clin Infect Dis, 46(6): 831-9.

BACKGROUND: Until recently, cytomegalovirus (CMV) infection represented a major threat to lung transplant recipients. Preliminary studies have shown that antiviral prophylaxis might improve the outcome for these patients. METHODS: We extended our initial pilot trial of prolonged prophylaxis with either oral ganciclovir (1 g 3 times per day) or valganciclovir (450 mg twice per day). The trial included 96 patients who were at risk for CMV-related events. RESULTS: CMV prophylaxis resulted in a ... [Abstract] [Full-text]

Articles on Bronchitis published 18 February 2008:

Diffuse lymphoplasmacytic bronchiolitis in cartilage-hair hypoplasia.   J Pediatr, 152(3): 429-33.

Three children with cartilage-hair hypoplasia presented with chronic obstructive symptoms and bronchiolar wall thickening on high-resolution computed tomography scanning. In all children, surgical lung biopsy demonstrated diffuse dilated lymphoplasmacytic bronchiolitis. The bronchiolar wall was infiltrated by a lymphocyte sheath with plasma cell differentiation and dispersed secondary follicles. Clarithromycin substantially improved respiratory symptoms and pulmonary function, allowing children ... [Abstract] [Full-text]

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