Bronchitis Research Today is a free monthly online journal that collates and summarizes the latest research about Bronchitis, including details on pulmonary disorders, symptoms, diagnosis, treatment, prevention.

The relationship between RSV bronchiolitis and recurrent wheeze: the chicken and the egg.

Bont L, Ramilo O

University Medical Centre Utrecht, Department of Pediatrics, PO Box 85090, 3508 AB, Utrecht, Netherlands. l.bont@umcutrecht.nl

Respiratory syncytial virus bronchiolitis is the most frequent cause of infant hospitalization. RSV bronchiolitis is often followed by recurrent episodes of wheeze. Pathogenesis of RSV bronchiolitis as well as post-bronchiolitis wheeze are incompletely understood. The aim of this review is to provide a brief overview of our current understanding of the complex pathogenesis of RSV bronchiolitis and post-bronchiolitis wheeze. Two non-exclusive hypotheses exist, which are paraphrased for this review as "the chicken and the egg". First, we reviewed the pre-existent genetic, pulmonary and immunological mechanisms of RSV bronchiolitis and post-bronchiolitis wheeze. Second, RSV as the causative virus of long-term airway morbidity is reviewed. Clearly, RSV infection is capable of causing direct damage to the airways and/or inducing long-term inappropriate immune responses to respiratory viruses or aero-allergens. It is concluded that intervention trials aimed at preventing RSV infections are required to establish the relative contribution of both RSV-induced and pre-existent mechanisms to the development of long-term airway disease following RSV bronchiolitis.

Published 25 February 2011 in Early Hum Dev, 87: S51-4.
Full-text of this article is available online (may require subscription).

Articles on Bronchitis published 20 January 2011:

Steam inhalation or humidified oxygen for acute bronchiolitis in children up to three years of age.   Cochrane Database Syst Rev, 1: CD006435.

[Abstract] [Full-text]

WITHDRAWN: Inhaled corticosteroids during acute bronchiolitis in the prevention of post-bronchiolitic wheezing.   Cochrane Database Syst Rev, 1: CD004881.

[Abstract] [Full-text]

Articles on Bronchitis published 18 January 2011:

Immunosuppression-induced bronchial epithelial-mesenchymal transition: a potential contributor to obliterative bronchiolitis.   J Thorac Cardiovasc Surg, 141(2): 523-30.

[Abstract] [Full-text]

Immunosuppression-induced bronchial epithelial-mesenchymal transition: a potential contributor to obliterative bronchiolitis.   J Thorac Cardiovasc Surg, 141(2): 523-30.

[Abstract] [Full-text]

Articles on Bronchitis published 3 January 2011:

Clinical prediction rule for RSV bronchiolitis in healthy newborns: prognostic birth cohort study.   Pediatrics, 127(1): 35-41.

[Abstract] [Full-text]

Articles on Bronchitis published 28 December 2010:

Airway hyperresponsiveness to adenosine 5'-monophosphate in feline chronic inflammatory lower airway disease.   Vet J, 187(1): 54-9.

Airway hyperresponsiveness is a key feature of human asthma and chronic bronchitis and response to the indirectly acting agonist adenosine 5'-monophosphate (AMP) is thought to reflect underlying airway inflammation. To examine whether airway responsiveness testing (ART) with AMP may be used to differentiate healthy cats from those with asthma (FA) and chronic bronchitis (CB), 24 cats (9 FA, 6 CB, 9 controls) underwent ART with AMP at concentrations of 0.1, 1, 10, 100 and 500mg/mL using ... [Abstract] [Full-text]

Airway hyperresponsiveness to adenosine 5'-monophosphate in feline chronic inflammatory lower airway disease.   Vet J, 187(1): 54-9.

Airway hyperresponsiveness is a key feature of human asthma and chronic bronchitis and response to the indirectly acting agonist adenosine 5'-monophosphate (AMP) is thought to reflect underlying airway inflammation. To examine whether airway responsiveness testing (ART) with AMP may be used to differentiate healthy cats from those with asthma (FA) and chronic bronchitis (CB), 24 cats (9 FA, 6 CB, 9 controls) underwent ART with AMP at concentrations of 0.1, 1, 10, 100 and 500mg/mL using ... [Abstract] [Full-text]

Articles on Bronchitis published 22 November 2010:

A case of follicular bronchiolitis associated with asthma, eosinophilia, and increased immunoglobulin E.   J Asthma, 47(10): 1161-4.

A 49-year-old woman, who had been diagnosed with asthma, showed a bilateral diffuse pattern of small centrilobular nodules on CT. Laboratory data revealed peripheral eosinophilia and a marked increase in total serum IgE levels. The nodules detected on CT were initially considered to be associated with bronchiolar infiltration of eosinophils. Pathological findings from thoracoscopy revealed infiltration of eosinophils into the airway lumen and walls, goblet cell hyperplasia, and thickening of ... [Abstract] [Full-text]

© 2005-2011 Bronchitis Research Today. All Rights Reserved.